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Jibi Thankachan

Jibi Thankachan

Tertiary Care Hospital, UK

Title: “Neonatal Sepsis”- Gram Positive & Negative Bacteria’s and their Antibiotic Susceptibility in NICU

Biography

Biography: Jibi Thankachan

Abstract

Back Ground:

Neonatal sepsis is one of the most common causes of Neonatal Mortality and Morbidity in developing countries. Its causative bacteria’s and their sensitive patterns are different in each hospitals and regions. The objective of the study was to determine the causation bacteria’s and their pattern of susceptibility to antibiotic s in NICU of a tertiary care center.

Material and Methods:

The prospective study was carried out at a tertiary care hospital during the period from January 2020 to January 2021. A total of 1712 blood cultures sent from different sites of the patients in NICU during this period. Out of which 1011 cultures came with positive bacterial growth (Includes gram +ve & -ve, Cons and other Recognized pathogens). All cultures were screened by using a micro ESR & Culture and Sensitivity methods.

Results:

A total of 1011 cultures were found to be positive out of 1712 cultures sent. Out of 1011 positive cultures 450+ are of gram positive organisms and remaining are of positive results with growth. The most common organisms isolated was Staph Epidermidis (68%), followed by Staph Heamolyticus (10%), Staph Hominis(7%), Enterococcus Fecalis(5%). Other Organisms where much less in number which includes Pathogenic Streptococcus, Enterococcus Feacium, Staph Capitis, Bacillus Species etc. There was Incidence of Gram Negative Organisms like E - Coli, Proteus Mirabilis, Serratia Marcescens were also got isolated from Cultures. The Gram Positive Organisms except Streptococcus displayed a high degree of resistance to most Penicillin and Ciprofloxacin and were most time sensitive to Vancomycin, Amikacin and Cefepime. In some cases high incidence of resistance noted with Ampicillin, Gentamicin amongst most Gram Negative Organisms, where in Cefepime, Amikacin and Meropenem were effective in most cases

Conclusion:

There is an increasing trend of antibiotic resistance to the commonly used front line drugs. Continuo’s surveillance for antibiotic susceptibility is needed to ensure proper empirical therapy.